THE RELATIONSHIP BETWEEN QUERCETIN AND HEALTH FROM THE PERSPECTIVE OF EPIGENETICS
Nội dung chính của bài viết
Tóm tắt
Background: Research on free radicals has been one of the topics that have attracted scientific and medical attention for decades, especially about ageing, disease, and infectious and non-infectious diseases. Exposure to free radicals from daily pollution and unhealthy lifestyles accelerates bodily damage and aging. These factors are primary contributors to gene and chromatin dysregulation, leading to chronic diseases such as metabolic disorders, allergies, cancer, etc.
Scope and approach: In the present literature, quercetin has been shown to have the ability to neutralize free radicals, reduce the formation of inflammatory cytokines, induce histamine release, and induce cell damage. At the same time, they have been shown to inhibit the growth of some inflammatory bacteria in the body, reversing the epigenetic mechanism of the disease. Moreover, quercetin has also been shown to have the ability to improve the body's immune system, help the body stay healthy, and overwhelm health hazards from the external environment. These roles of quercetin in health are reviewed from the latest advances in epigenetics.
Key findings and conclusions: Quercetin plays an important role in the treatment of human diseases through epigenetic mechanisms. Quercetin's potential to reverse the epigenetic mechanism for pathology requires further investigation to obtain a general view.
Chi tiết bài viết
Từ khóa
Epigenetic, quercetin, antioxidant, reactive oxygen species, autophagy
Tài liệu tham khảo
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7. Chac L, Thinh B, Huong H, Kiet N, Huan L. Quantification of quercetin, isorhamnetin and ferulic acid in dry extract of Anoectochilus setaceus Blume from Vietnam. International Journal of Botany Studies. 2019;4(5):14-18.
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10. Zhu X, Xiong T, Liu P, Guo X, Xiao L, Zhou F, et al. Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018;114:52-60.
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13. Dabeek WM, Marra MV. Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients. 2019;11(10). doi:10.3390/nu11102288.
14. Nile A, Nile SH, Shin J, Park G, Oh JW. Quercetin-3-Glucoside Extracted from Apple Pomace Induces Cell Cycle Arrest and Apoptosis by Increasing Intracellular ROS Levels. International journal of molecular sciences. 2021;22(19). doi:10.3390/ijms221910749.
15. Larson A, Symons J, Jalili T. Therapeutic Potential of Quercetin to Decrease Blood Pressure: Review of Efficacy and Mechanisms. Advances in nutrition (Bethesda, Md). 2012;3:39-46.
16. Sezer ED, Oktay LM, Karadadaş E, Memmedov H, Selvi Gunel N, Sözmen E. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells. Journal of medicinal food. 2019;22(11):1118-26. doi:10.1089/jmf.2019.0098.
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18. Yasin G, Jasim S, Mahmudiono T, Al-Shawi S, Shichiyakh R, Shoukat S, et al. Investigating the effect of garlic (Allium sativum) essential oil on foodborne pathogenic microorganisms. Food Science and Technology. 2022;42. doi:10.1590/fst.03822.
19. Yang J, Chen X, Rao S, Li Y, Zang Y, Zhu B. Identification and Quantification of Flavonoids in Okra (Abelmoschus esculentus L. Moench) and Antiproliferative Activity In Vitro of Four Main Components Identified. Metabolites. 2022;12(6). doi:10.3390/metabo12060483.
20. Hwang IK, Lee CH, Yoo KY, Choi JH, Park OK, Lim SS, et al. Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. Journal of medicinal food. 2009;12(5):990-5. doi:10.1089/jmf.2008.1400.
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