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Date Published:
28/08/2025
Online Published:
15/08/2025
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1.
Nguyễn ĐP, Hoang THY, Hoang KL. NUTRITIONAL OVERVIEW FOR PREVENTION OF OSTEOPOROSIS IN KIDNEY TRANPLANT RECIPIENTS. Tạp chí Dinh dưỡng và Thực phẩm. 2025;21(4):1-12. doi:10.56283/1859-0381/943
NUTRITIONAL OVERVIEW FOR PREVENTION OF OSTEOPOROSIS IN KIDNEY TRANPLANT RECIPIENTS
Main Article Content
Abstract
Osteoporosis is a common condition in post-kidney transplant patients due to various causes. This condition progresses silently over an extended period and can lead to serious consequences such as fractures, reduced quality of life, and exacerbation of underlying diseases. Therefore, early monitoring, prevention, and treatment of this condition are crucial. Nutrition is a safe and essential supportive measure for these patients. However, it remains a relatively new area with no unified recommendations for post-kidney transplant patients. In this article, we summarize all aspects of nutritional supplementation related to osteoporosis, aiming to support the selection and consideration of the most appropriate and comprehensive nutritional strategies to minimize the impact of bone-related disorders on post-kidney transplant patients.
Keywords
Nutrition, prevention, osteoporosis, kidney transplant
Article Details
References
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4. Kyoung Jin Kim, Ha J, Sang Wan Kim, Kim JE, Lee S, Han Seok Choi, et al. Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations. Endocrinology and metabolism. 2024 Apr 30;39(2):267–82. doi:10.3803/EnM.2024.1939.
5. Alshayeb HM, Josephson MA, Sprague SM. CKD–Mineral and Bone Disorder Management in Kidney Transplant Recipients. American Journal of Kidney Diseases. 2013 Feb;61(2):310–25. doi:10.1053/j.ajkd.2012.07.022.
6. Kurnool S, Shah N, Ekanayake P. Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach. Therapeutic Advances in Endocrinology and Metabolism. 2025 Jun 14;16. doi:10.1177/20420188251347351.
7. Bộ Y tế. Bệnh suy thận ngày càng gia tăng và trẻ hóa [Internet]. Hà Nội: Bộ Y tế; 05 Jul 2025. Available from: https://moh.gov.vn/home?p_p_id=101&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&_101_struts_action=%2Fasset_publisher%2Fview_content&_101_type=content&_101_urlTitle=benh-suy-than-ngay-cang-gia-tang-va-tre-hoa.
8. NHS. Benefits and risks of a kidney transplant [Internet]. Organ transplantation - NHS Blood and Transplant. 2022. Available from: https://www.nhsbt.nhs.uk/organ-transplantation/kidney/benefits-and-risks-of-a-kidney-transplant/.
9. Atkinson SA, Ward WE. Clinical nutrition: 2. The role of nutrition in the prevention and treatment of adult osteoporosis. Cmaj. 2001;165(11):1511-4.
10. Teh JW, Conall Mac Gearailt, David. Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management. International Journal of Molecular Sciences. 2024 Feb 3;25(3):1859–9. doi:10.3390/ijms25031859.
11. Zhang R. Metabolic bone diseases in kidney transplant recipients. World Journal of Nephrology. 2012;1(5):127. doi:10.5527/wjn.v1.i5.127.
12. Post-Transplant Bone Disease [Internet]. National Kidney Foundation. 2024. Available from: https://www.kidney.org/post-transplant-bone-disease.
13. Molnar MZ, Naser MS, Rhee CM, Kamyar Kalantar-Zadeh, Suphamai Bunnapradist. Bone and mineral disorders after kidney transplantation: Therapeutic strategies. Transplantation reviews. 2014 Apr 1;28(2):56–62. doi:10.1016/j.trre.2013.12.003.
14. Recommendations of the Spanish Menopause Society on the consumption of omega-3 polyunsaturated fatty acids by postmenopausal women. Maturitas [Internet]. 2017 Sep 1;103:71–7. Available from: https://www.sciencedirect.com/science/article/pii/S0378512217306229.
15. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients [Internet]. 2020 May 19;12(5). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285165/.
16. Yu RW, Faull RJ, Coates PTH, Coates PS. Calcium supplements lower bone resorption after renal transplant. Clinical Transplantation. 2011 Aug 21;26(2):292–9.
17. Karpouzos A, Diamantis E, Farmaki P, Savvanis S, Troupis T. Nutritional aspects of bone health and fracture healing. Journal of Osteoporosis [Internet]. 2017;2017(4218472):1–10. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804294/.
18. Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. The Open Orthopaedics Journal [Internet]. 2012 Apr 5;6(1):143–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330619/.
19. Sunyecz JA. The Use of Calcium and Vitamin D in the Management of Osteoporosis. Therapeutics and Clinical Risk Management [Internet]. 2008 Aug;4(4):827–36. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621390/.
20. Heaney RP. Calcium intake and disease prevention. Arquivos Brasileiros de Endocrinologia & Metabologia. 2006 Aug;50(4):685–93. doi:10.1590/s0004-27302006000400014.
21. Sihem Benaboud, Saïk Urien, Thervet E, Prié D, Legendre C, Jean-Claude Souberbielle, et al. Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach. European Journal of Clinical Pharmacology. 2012 Aug 30;69(3):499–506. doi:10.1007/s00228-012-1378-3.
22. Courbebaisse M, Thervet E, Souberbielle JC, Zuber J, Eladari D, Martinez F, et al. Effects of vitamin D supplementation on the calcium–phosphate balance in renal transplant patients. Kidney International. 2009 Mar;75(6):646–51. doi:10.1038/ki.2008.549.
23. Wissing KM, Broeders N, Moreno-Reyes R, Gervy C, Stallenberg B, Abramowicz D. A Controlled Study of Vitamin D3 to Prevent Bone Loss in Renal-Transplant Patients Receiving Low Doses of Steroids. Transplantation. 2005 Jan 15;79(1):108–15. doi:10.1097/01.TP.0000149322.70295.A5.
24. Bhoi S, Pal A, Das A. Effect of Calcium and Vitamin D on Bone Health among Kidney Transplant Recipients in a Prospective Randomized Controlled Trial. Indian Journal of Transplantation. 2024 Jul;18(3):282–9. doi:10.4103/ijot.ijot_141_23.
25. Heaney RP. Vitamin D and calcium interactions: functional outcomes. The American Journal of Clinical Nutrition. 2008 Aug 1;88(2):541S544S. doi: 10.1093/ajcn/88.2.541S.
26. Molinari P, Alfieri C, Mattinzoli D, Campise M, Cervesato A, Malvica S, et al. Bone and Mineral Disorder in Renal Transplant Patients: Overview of Pathology, Clinical, and Therapeutic Aspects. Frontiers in Medicine [Internet]. 2022 Mar 10 [cited 2023 Dec 3];9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960161/
27. Moshfegh AJ, Kovalchik AF, Clemens JC. Phosphorus Intake of Americans: What We Eat In America, NHANES 2011-2012. FSRG Dietary Data Briefs [Internet]. 2016 Sep; Available from: https://pubmed.ncbi.nlm.nih.gov/36862822/.
28. Ahn CB, Je JY. Bone health-promoting bioactive peptides. Journal of Food Biochemistry. 2018 Feb 21;43(1):e12529. doi:10.1111/jfbc.12529.
29. Sun S, Liu F, Liu G, Miao J, Xiao H, Xiao J, et al. Effects of casein phosphopeptides on calcium absorption and metabolism bioactivity in vitro and in vivo. Food & Function. 2018 Jan 1;9(10):5220–9. doi:10.1039/C8FO00401C.
30. Cardoso DF, Marques EA, Leal DV, Ferreira A, Baker LA, Smith AC, et al. Impact of physical activity and exercise on bone health in patients with chronic kidney disease: a systematic review of observational and experimental studies. BMC Nephrology. 2020 Aug 8;21(1). doi:10.1186/s12882-020-01999-z.
31. Eatemadololama A. Resistance exercise training restores bone mineral density in renal transplant recipients. Clinical Cases in Mineral and Bone Metabolism. 2017;14(2):157. doi:10.11138/ccmbm/2017.14.1.157.
32. Wilkinson TJ, Bishop NC, Billany RE, Lightfoot CJ, Castle EM, Smith AC, et al. The effect of exercise training interventions in adult kidney transplant recipients: a systematic review and meta-analysis of randomised control trials. Physical Therapy Reviews. 2021 Dec 10;27(2):114–34. doi: 10.1080/10833196.2021.2002641.
33. Dimitri Stylemans, Marieke Vandecruys, Sofie Leunis, Sofie Engelborghs, Davide Gargioli, Diethard Monbaliu, et al. Physical Exercise After Solid Organ Transplantation: A Cautionary Tale. Transplant international. 2024 Feb 13;37. doi: 10.3389/ti.2024.12448.
2. E. Michael Lewiecki. Osteoporosis: Clinical Evaluation [Internet]. Nih.gov. MDText.com, Inc.; 2024. Available from: http://www.ncbi.nlm.nih.gov/books/NBK279049/.
3. Park WY, Han S, Choi BS, Park CW, Yang CW, Kim YS, et al. Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease. Transplantation Proceedings. 2017 Jun 1;49(5):1033–7. doi:10.1016/j.transproceed.2017.03.038.
4. Kyoung Jin Kim, Ha J, Sang Wan Kim, Kim JE, Lee S, Han Seok Choi, et al. Bone Loss after Solid Organ Transplantation: A Review of Organ-Specific Considerations. Endocrinology and metabolism. 2024 Apr 30;39(2):267–82. doi:10.3803/EnM.2024.1939.
5. Alshayeb HM, Josephson MA, Sprague SM. CKD–Mineral and Bone Disorder Management in Kidney Transplant Recipients. American Journal of Kidney Diseases. 2013 Feb;61(2):310–25. doi:10.1053/j.ajkd.2012.07.022.
6. Kurnool S, Shah N, Ekanayake P. Treatment of osteoporosis in the solid organ transplant recipient: an organ-based approach. Therapeutic Advances in Endocrinology and Metabolism. 2025 Jun 14;16. doi:10.1177/20420188251347351.
7. Bộ Y tế. Bệnh suy thận ngày càng gia tăng và trẻ hóa [Internet]. Hà Nội: Bộ Y tế; 05 Jul 2025. Available from: https://moh.gov.vn/home?p_p_id=101&p_p_lifecycle=0&p_p_state=maximized&p_p_mode=view&_101_struts_action=%2Fasset_publisher%2Fview_content&_101_type=content&_101_urlTitle=benh-suy-than-ngay-cang-gia-tang-va-tre-hoa.
8. NHS. Benefits and risks of a kidney transplant [Internet]. Organ transplantation - NHS Blood and Transplant. 2022. Available from: https://www.nhsbt.nhs.uk/organ-transplantation/kidney/benefits-and-risks-of-a-kidney-transplant/.
9. Atkinson SA, Ward WE. Clinical nutrition: 2. The role of nutrition in the prevention and treatment of adult osteoporosis. Cmaj. 2001;165(11):1511-4.
10. Teh JW, Conall Mac Gearailt, David. Post-Transplant Bone Disease in Kidney Transplant Recipients: Diagnosis and Management. International Journal of Molecular Sciences. 2024 Feb 3;25(3):1859–9. doi:10.3390/ijms25031859.
11. Zhang R. Metabolic bone diseases in kidney transplant recipients. World Journal of Nephrology. 2012;1(5):127. doi:10.5527/wjn.v1.i5.127.
12. Post-Transplant Bone Disease [Internet]. National Kidney Foundation. 2024. Available from: https://www.kidney.org/post-transplant-bone-disease.
13. Molnar MZ, Naser MS, Rhee CM, Kamyar Kalantar-Zadeh, Suphamai Bunnapradist. Bone and mineral disorders after kidney transplantation: Therapeutic strategies. Transplantation reviews. 2014 Apr 1;28(2):56–62. doi:10.1016/j.trre.2013.12.003.
14. Recommendations of the Spanish Menopause Society on the consumption of omega-3 polyunsaturated fatty acids by postmenopausal women. Maturitas [Internet]. 2017 Sep 1;103:71–7. Available from: https://www.sciencedirect.com/science/article/pii/S0378512217306229.
15. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients [Internet]. 2020 May 19;12(5). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285165/.
16. Yu RW, Faull RJ, Coates PTH, Coates PS. Calcium supplements lower bone resorption after renal transplant. Clinical Transplantation. 2011 Aug 21;26(2):292–9.
17. Karpouzos A, Diamantis E, Farmaki P, Savvanis S, Troupis T. Nutritional aspects of bone health and fracture healing. Journal of Osteoporosis [Internet]. 2017;2017(4218472):1–10. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804294/.
18. Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. The Open Orthopaedics Journal [Internet]. 2012 Apr 5;6(1):143–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330619/.
19. Sunyecz JA. The Use of Calcium and Vitamin D in the Management of Osteoporosis. Therapeutics and Clinical Risk Management [Internet]. 2008 Aug;4(4):827–36. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621390/.
20. Heaney RP. Calcium intake and disease prevention. Arquivos Brasileiros de Endocrinologia & Metabologia. 2006 Aug;50(4):685–93. doi:10.1590/s0004-27302006000400014.
21. Sihem Benaboud, Saïk Urien, Thervet E, Prié D, Legendre C, Jean-Claude Souberbielle, et al. Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach. European Journal of Clinical Pharmacology. 2012 Aug 30;69(3):499–506. doi:10.1007/s00228-012-1378-3.
22. Courbebaisse M, Thervet E, Souberbielle JC, Zuber J, Eladari D, Martinez F, et al. Effects of vitamin D supplementation on the calcium–phosphate balance in renal transplant patients. Kidney International. 2009 Mar;75(6):646–51. doi:10.1038/ki.2008.549.
23. Wissing KM, Broeders N, Moreno-Reyes R, Gervy C, Stallenberg B, Abramowicz D. A Controlled Study of Vitamin D3 to Prevent Bone Loss in Renal-Transplant Patients Receiving Low Doses of Steroids. Transplantation. 2005 Jan 15;79(1):108–15. doi:10.1097/01.TP.0000149322.70295.A5.
24. Bhoi S, Pal A, Das A. Effect of Calcium and Vitamin D on Bone Health among Kidney Transplant Recipients in a Prospective Randomized Controlled Trial. Indian Journal of Transplantation. 2024 Jul;18(3):282–9. doi:10.4103/ijot.ijot_141_23.
25. Heaney RP. Vitamin D and calcium interactions: functional outcomes. The American Journal of Clinical Nutrition. 2008 Aug 1;88(2):541S544S. doi: 10.1093/ajcn/88.2.541S.
26. Molinari P, Alfieri C, Mattinzoli D, Campise M, Cervesato A, Malvica S, et al. Bone and Mineral Disorder in Renal Transplant Patients: Overview of Pathology, Clinical, and Therapeutic Aspects. Frontiers in Medicine [Internet]. 2022 Mar 10 [cited 2023 Dec 3];9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8960161/
27. Moshfegh AJ, Kovalchik AF, Clemens JC. Phosphorus Intake of Americans: What We Eat In America, NHANES 2011-2012. FSRG Dietary Data Briefs [Internet]. 2016 Sep; Available from: https://pubmed.ncbi.nlm.nih.gov/36862822/.
28. Ahn CB, Je JY. Bone health-promoting bioactive peptides. Journal of Food Biochemistry. 2018 Feb 21;43(1):e12529. doi:10.1111/jfbc.12529.
29. Sun S, Liu F, Liu G, Miao J, Xiao H, Xiao J, et al. Effects of casein phosphopeptides on calcium absorption and metabolism bioactivity in vitro and in vivo. Food & Function. 2018 Jan 1;9(10):5220–9. doi:10.1039/C8FO00401C.
30. Cardoso DF, Marques EA, Leal DV, Ferreira A, Baker LA, Smith AC, et al. Impact of physical activity and exercise on bone health in patients with chronic kidney disease: a systematic review of observational and experimental studies. BMC Nephrology. 2020 Aug 8;21(1). doi:10.1186/s12882-020-01999-z.
31. Eatemadololama A. Resistance exercise training restores bone mineral density in renal transplant recipients. Clinical Cases in Mineral and Bone Metabolism. 2017;14(2):157. doi:10.11138/ccmbm/2017.14.1.157.
32. Wilkinson TJ, Bishop NC, Billany RE, Lightfoot CJ, Castle EM, Smith AC, et al. The effect of exercise training interventions in adult kidney transplant recipients: a systematic review and meta-analysis of randomised control trials. Physical Therapy Reviews. 2021 Dec 10;27(2):114–34. doi: 10.1080/10833196.2021.2002641.
33. Dimitri Stylemans, Marieke Vandecruys, Sofie Leunis, Sofie Engelborghs, Davide Gargioli, Diethard Monbaliu, et al. Physical Exercise After Solid Organ Transplantation: A Cautionary Tale. Transplant international. 2024 Feb 13;37. doi: 10.3389/ti.2024.12448.
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