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EFFECTIVENESS OF KENU TM CAPSULES IN SUPPORTING LIPID-LOWERING TREATMENT IN PATIENTS WITH HYPERCHOLESTEROLEMIA
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Abstract
Aims: To evaluate the effectiveness of Kenu TM capsules in supporting lipid-lowering treatment of in patients with hypercholesterolemia.
Methods: A randomized open-label clinical trial was conducted on 487 patients with hypercholesterolemia. The subjects were divided into two groups, high cardiovascular risk group, and low cardiovascular risk group, according to the American Heart Association and American College of Cardiology 2018 recommendations. In each group, the subjects were randomly assigned to the intervention and control groups. The intervention group used Kenu TM capsules for three months.
Results: After three months, plasma cholesterol concentration decreased more in the intervention group than that in the control group (low cardiovascular risk and high cardiovascular risk group: 0.9 ± 1.4 versus -0.1 ±1.9; 0.9 ± 1.4 versus 0.1 ± 1.0 mmol/L, respectively), p < 0.05. Kenu TM capsules were effective in reducing the number of patients with hypercholesterolemia by 1.7 times with RR (95%CI): 1.7 (1.1-2.5) in the low cardiovascular risk group and 2.6 times with RR (95%CI): 2.6 (1.6-4.3) in the high cardiovascular risk group compared with the control group. After 3 months, plasma triglyceride concentration decreased more in the intervention group than that in the control group (low cardiovascular risk and high cardiovascular risk group: 1.2 ± 2.4 versus -0.8 ± 2.5; 1.5 ± 3.2 versus -0.7 ± 3.2 mmol/L, respectively) with p < 0.05.
Conclusion: Kenu TM capsules could have had the effect of reducing plasma cholesterol, and triglyceride in patients with hypercholesterolemia after three months.
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Keywords
Hypercholesterolemia, 𝘓𝘢𝘤𝘵𝘰𝘣𝘢𝘤𝘪𝘭𝘶𝘴 𝘱𝘭𝘢𝘯𝘵𝘢𝘳𝘶𝘮
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