CẬP NHẬT VỀ CAN THIỆP SYNBIOTICS TRONG CẢI THIỆN TÌNH TRẠNG DINH DƯỠNG VÀ SỨC KHỎE Ở TRẺ EM
Nội dung chính của bài viết
Tóm tắt
Synbiotics có nhiều tác động tích cực đối với sức khỏe của con người. Nghiên cứu này nhằm tổng hợp, phân tích các cập nhật về bổ sung synbiotics, tác dụng của synbiotics đối với sức khỏe và tình trạng dinh dưỡng của trẻ em, từ đó khuyến nghị các hướng phát triển tiếp theo của synbiotics trong cải thiện dinh dưỡng và sức khỏe của trẻ em tại Việt Nam. Phương pháp nghiên cứu sử dụng nguồn dữ liệu tại các cơ sở dữ liệu, thư viện điện tử y học uy tín PubMed/MEDLINE, Scopus, EMBASE, ISI Web of Science và Cochrane Library và công cụ tìm kiếm Google và Google Scholar. Kết quả:18 nghiên cứu từ 2016 đến 2024 được đưa vào nghiên cứu.
Kết quả cho thấy bổ sung synbiotics có thể có tác dụng hỗ trợ kiểm soát cân nặng ở trẻ em thừa cân béo phì, hỗ trợ tích cực điều trị táo bón cơ năng và tiêu chảy ở trẻ em. Synbiotics cũng có tác dụng tăng cường miễn dịch và hỗ trợ điều trị các bệnh lý dị ứng, miễn dịch và có tác động đáng chú ý trên người bệnh mắc chứng rối loạn tăng động giảm chú ý. Tuy nhiên cần có nhiều nghiên cứu với mẫu lớn, thời gian can thiệp đủ lâu để có thể đưa ra các khuyến cáo đầy đủ bằng chứng hơn.
Chi tiết bài viết
Từ khóa
Synbiotics, trẻ em, tình trạng dinh dưỡng, hệ vi khuẩn đường ruột
Tài liệu tham khảo
1. Swanson KS, Gibson GR, Hutkins R, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687-701.
2. Sommermeyer H, Piątek J. Synbiotics as Treatment for Irritable Bowel Syndrome: A Review. Microorganisms. 2024;12(7):1493. doi:10.3390/microorganisms12071493
3. Araújo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Front Nutr. 2022;9:935830.
4. Markowiak-Kopeć P, Slizewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9:1021. doi:10.3390/nu9091021
5. Sharma AN, Chaudhary P, Kumar S, Grover CR, Mondal G. Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves. Sci Rep. 2023;13(1):10184. doi:10.1038/s41598-023-37002-6
6. Arteaga-Henríquez G, Ramos-Sayalero C, Ibañez-Jimenez P, et al. Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, “basket” trial. Brain Behav Immun. 2024;120:360-371.
7. Allahyari P, Abbas Torki S, Aminnezhad Kavkani B, et al. A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD. Neuropsychopharmacol Rep. 2024;44(2):300-307.
8. Borka Balas R, Meliț LE, Lupu A, Lupu VV, Mărginean CO. Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity. Microorganisms. 2023;11(11):2651.
9. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71
10. Higgins JP, Altman DG. Assessing Risk of Bias in Included Studies. In: Cochrane Handbook for Systematic Reviews of Interventions. John Wiley & Sons, Ltd; 2008:187-241.
11. Kilic Yildirim G, Dinleyici M, Vandenplas Y, Dinleyici EC. Effects of Multispecies Synbiotic Supplementation on Anthropometric Measurements, Glucose and Lipid Parameters in Children With Exogenous Obesity: A Randomized, Double Blind, Placebo-Controlled Clinical Trial (Probesity-2 Trial). Front Nutr. 2022;9. doi:10.3389/fnut.2022.898037
12. Atazadegan MA, Heidari-Beni M, Entezari MH, Sharifianjazi F, Kelishadi R. Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents: a randomized, double-blind, placebo-controlled clinical trial. World J Pediatr. 2023;19(4):356-365.
13. Kilic Yildirim G, Dinleyici M, Vandenplas Y, Dinleyici EC. Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial). Gut Pathog. 2023;15(1):36.
14. Basturk A, Artan R, Atalay A, Yilmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28(5):388-393.
15. Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey, Basturk A, Artan R, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey, Yilmaz A, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2020;27(5):439-443.
16. Yang LL, Stiernborg M, Skott E, et al. Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD—A Randomized Controlled Trial. Nutrients. 2023;15(5):1293. doi:10.3390/nu15051293
17. Skott E, Yang LL, Stiernborg M, et al. Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder – A double-blind randomized controlled trial. Brain Behav Immun. 2020;89:9-19.
18. Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83(3):677-686.
19. Dissanayake E, Tani Y, Nagai K, et al. Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial. Int Arch Allergy Immunol. 2019;180(3):202-211.
20. Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, et al. The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2–5 Years. Probiotics Antimicrob Proteins. 2020;12(1):119-124.
21. Scheuchzer P, Sinawat S, Donzé AS, et al. Iron Absorption from an Iron-Fortified Follow-Up Formula with and without the Addition of a Synbiotic or a Human-Identical Milk Oligosaccharide: A Randomized Crossover Stable Isotope Study in Young Thai Children. J Nutr. Published online August 22, 2024. doi:10.1016/j.tjnut.2024.08.016
22. Chatchatee P, Nowak-Wegrzyn A, Lange L, et al. Tolerance development in cow’s milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study). J Pediatr Gastroenterol Nutr. 2024;78(3):699-703.
23. Kianifar HR, Ahanchian H, Safarian M, et al. Effects of Synbiotics on Anthropometric Indices of Obesity in Children: A Randomized Double-Blind Placebo-Controlled Pilot Study. Top Clin Nutr. 2018;33(2):118. doi:10.1097/TIN.0000000000000134
24. Tierney BT, Versalovic J, Fasano A, et al. Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial. Pediatr Res. 2023;93(7):2005-2013.
25. Goli M, Pourmoghaddas Z, Emadoleslami MS, Rahimi H. The Effectiveness of Synbiotics in Preventing Antibiotic-Associated Diarrhea in Children: A Double-Blind Randomized Clinical Trial. Arch Pediatr Infect Dis. 2019;7(4). doi:10.5812/pedinfect.89707
26. Helmyati S, Shanti KM, Sari FT, et al. Synbiotic Fermented Milk with Double Fortification (Fe-Zn) as a Strategy to Address Stunting: A Randomized Controlled Trial among Children under Five in Yogyakarta, Indonesia. Processes. 2021;9(3):543. doi:10.3390/pr9030543
27. Hassanzad M, Maleki Mostashari K, Ghaffaripour H, Emami H, Rahimi Limouei S, Velayati AA. Synbiotics and Treatment of Asthma: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial. Galen Med J. 2019;8:e1350. doi:10.31661/gmj.v8i0.1350
28. Duraisamy V, Geethapriya PR, Bharath C, Niveditha RS, John JB. Role of probiotics and synbiotics on inhibiting Streptococcus mutans level in saliva of children: A randomized controlled trial. J Indian Soc Pedod Prev Dent. 2021;39(3):275.
29. Noormohammadi M, Ghorbani Z, Löber U, et al. The effect of probiotic and synbiotic supplementation on appetite-regulating hormones and desire to eat: A systematic review and meta-analysis of clinical trials. Pharmacol Res. 2023;187:106614.
30 . Wu T, Wang G, Xiong Z, et al. Probiotics Interact With Lipids Metabolism and Affect Gut Health. Front Nutr. 2022;9. doi:10.3389/fnut.2022.917043
31. Yang B, Lu P, Li MX, et al. A meta-analysis of the effects of probiotics and synbiotics in children with acute diarrhea. Medicine (Baltimore). 2019;98(37):e16618.
32. Liu L, Wang A, Shi H, Tao H, Nahata MC. Efficacy and safety of probiotics and synbiotics for functional constipation in children: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr. 2023;42(10):1817-1826.
33. Meirlaen L, Levy EI, Vandenplas Y. Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. Nutrients. 2021;13(3):934. doi:10.3390/nu13030934
34. Xiong RG, Li J, Cheng J, et al. The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components. Nutrients. 2023;15(14):3258. doi:10.3390/nu15143258.
2. Sommermeyer H, Piątek J. Synbiotics as Treatment for Irritable Bowel Syndrome: A Review. Microorganisms. 2024;12(7):1493. doi:10.3390/microorganisms12071493
3. Araújo MM, Botelho PB. Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence. Front Nutr. 2022;9:935830.
4. Markowiak-Kopeć P, Slizewska K. Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients. 2017;9:1021. doi:10.3390/nu9091021
5. Sharma AN, Chaudhary P, Kumar S, Grover CR, Mondal G. Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves. Sci Rep. 2023;13(1):10184. doi:10.1038/s41598-023-37002-6
6. Arteaga-Henríquez G, Ramos-Sayalero C, Ibañez-Jimenez P, et al. Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, “basket” trial. Brain Behav Immun. 2024;120:360-371.
7. Allahyari P, Abbas Torki S, Aminnezhad Kavkani B, et al. A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD. Neuropsychopharmacol Rep. 2024;44(2):300-307.
8. Borka Balas R, Meliț LE, Lupu A, Lupu VV, Mărginean CO. Prebiotics, Probiotics, and Synbiotics—A Research Hotspot for Pediatric Obesity. Microorganisms. 2023;11(11):2651.
9. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. doi:10.1136/bmj.n71
10. Higgins JP, Altman DG. Assessing Risk of Bias in Included Studies. In: Cochrane Handbook for Systematic Reviews of Interventions. John Wiley & Sons, Ltd; 2008:187-241.
11. Kilic Yildirim G, Dinleyici M, Vandenplas Y, Dinleyici EC. Effects of Multispecies Synbiotic Supplementation on Anthropometric Measurements, Glucose and Lipid Parameters in Children With Exogenous Obesity: A Randomized, Double Blind, Placebo-Controlled Clinical Trial (Probesity-2 Trial). Front Nutr. 2022;9. doi:10.3389/fnut.2022.898037
12. Atazadegan MA, Heidari-Beni M, Entezari MH, Sharifianjazi F, Kelishadi R. Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents: a randomized, double-blind, placebo-controlled clinical trial. World J Pediatr. 2023;19(4):356-365.
13. Kilic Yildirim G, Dinleyici M, Vandenplas Y, Dinleyici EC. Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial). Gut Pathog. 2023;15(1):36.
14. Basturk A, Artan R, Atalay A, Yilmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28(5):388-393.
15. Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey, Basturk A, Artan R, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey, Yilmaz A, Department of Pediatric Gastroenterology, Akdeniz University School of Medicine, Antalya, Turkey. Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: A randomized controlled trial. Turk J Gastroenterol. 2020;27(5):439-443.
16. Yang LL, Stiernborg M, Skott E, et al. Effects of a Synbiotic on Plasma Immune Activity Markers and Short-Chain Fatty Acids in Children and Adults with ADHD—A Randomized Controlled Trial. Nutrients. 2023;15(5):1293. doi:10.3390/nu15051293
17. Skott E, Yang LL, Stiernborg M, et al. Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder – A double-blind randomized controlled trial. Brain Behav Immun. 2020;89:9-19.
18. Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83(3):677-686.
19. Dissanayake E, Tani Y, Nagai K, et al. Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial. Int Arch Allergy Immunol. 2019;180(3):202-211.
20. Aflatoonian M, Taghavi Ardakani A, Modarresi SZ, et al. The Effect of Synbiotic Supplementation on Growth Parameters in Mild to Moderate FTT Children Aged 2–5 Years. Probiotics Antimicrob Proteins. 2020;12(1):119-124.
21. Scheuchzer P, Sinawat S, Donzé AS, et al. Iron Absorption from an Iron-Fortified Follow-Up Formula with and without the Addition of a Synbiotic or a Human-Identical Milk Oligosaccharide: A Randomized Crossover Stable Isotope Study in Young Thai Children. J Nutr. Published online August 22, 2024. doi:10.1016/j.tjnut.2024.08.016
22. Chatchatee P, Nowak-Wegrzyn A, Lange L, et al. Tolerance development in cow’s milk-allergic children receiving amino acid-based formula with synbiotics: 36-Months follow-up of a randomized controlled trial (PRESTO Study). J Pediatr Gastroenterol Nutr. 2024;78(3):699-703.
23. Kianifar HR, Ahanchian H, Safarian M, et al. Effects of Synbiotics on Anthropometric Indices of Obesity in Children: A Randomized Double-Blind Placebo-Controlled Pilot Study. Top Clin Nutr. 2018;33(2):118. doi:10.1097/TIN.0000000000000134
24. Tierney BT, Versalovic J, Fasano A, et al. Functional response to a microbial synbiotic in the gastrointestinal system of children: a randomized clinical trial. Pediatr Res. 2023;93(7):2005-2013.
25. Goli M, Pourmoghaddas Z, Emadoleslami MS, Rahimi H. The Effectiveness of Synbiotics in Preventing Antibiotic-Associated Diarrhea in Children: A Double-Blind Randomized Clinical Trial. Arch Pediatr Infect Dis. 2019;7(4). doi:10.5812/pedinfect.89707
26. Helmyati S, Shanti KM, Sari FT, et al. Synbiotic Fermented Milk with Double Fortification (Fe-Zn) as a Strategy to Address Stunting: A Randomized Controlled Trial among Children under Five in Yogyakarta, Indonesia. Processes. 2021;9(3):543. doi:10.3390/pr9030543
27. Hassanzad M, Maleki Mostashari K, Ghaffaripour H, Emami H, Rahimi Limouei S, Velayati AA. Synbiotics and Treatment of Asthma: A Double-Blinded, Randomized, Placebo-Controlled Clinical Trial. Galen Med J. 2019;8:e1350. doi:10.31661/gmj.v8i0.1350
28. Duraisamy V, Geethapriya PR, Bharath C, Niveditha RS, John JB. Role of probiotics and synbiotics on inhibiting Streptococcus mutans level in saliva of children: A randomized controlled trial. J Indian Soc Pedod Prev Dent. 2021;39(3):275.
29. Noormohammadi M, Ghorbani Z, Löber U, et al. The effect of probiotic and synbiotic supplementation on appetite-regulating hormones and desire to eat: A systematic review and meta-analysis of clinical trials. Pharmacol Res. 2023;187:106614.
30 . Wu T, Wang G, Xiong Z, et al. Probiotics Interact With Lipids Metabolism and Affect Gut Health. Front Nutr. 2022;9. doi:10.3389/fnut.2022.917043
31. Yang B, Lu P, Li MX, et al. A meta-analysis of the effects of probiotics and synbiotics in children with acute diarrhea. Medicine (Baltimore). 2019;98(37):e16618.
32. Liu L, Wang A, Shi H, Tao H, Nahata MC. Efficacy and safety of probiotics and synbiotics for functional constipation in children: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr. 2023;42(10):1817-1826.
33. Meirlaen L, Levy EI, Vandenplas Y. Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. Nutrients. 2021;13(3):934. doi:10.3390/nu13030934
34. Xiong RG, Li J, Cheng J, et al. The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components. Nutrients. 2023;15(14):3258. doi:10.3390/nu15143258.