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31/10/2023
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Nguyễn PT, Nguyễn HT. ASTAXANTHIN TỪ VI TẢO: ỨNG DỤNG VÀ THÁCH THỨC TRONG QUÁ TRÌNH SẢN XUẤT VÀ THƯƠNG MẠI. Tạp chí Dinh dưỡng và Thực phẩm. 2023;19(4+5):1-10. doi:10.56283/1859-0381/557
ASTAXANTHIN TỪ VI TẢO: ỨNG DỤNG VÀ THÁCH THỨC TRONG QUÁ TRÌNH SẢN XUẤT VÀ THƯƠNG MẠI
Nội dung chính của bài viết
Tóm tắt
Astaxanthin nguồn gốc từ vi tảo gần đây đã thu hút được sự quan tâm bởi tiềm năng ứng dụng trong thực phẩm, dược phẩm dinh dưỡng, dược phẩm, thức ăn chăn nuôi, và mỹ phẩm. Astaxanthin được sử dụng như một chất bổ sung dinh dưỡng, chất chống oxy hóa, chống viêm, chống ung thư, kích thích miễn dịch. Astaxanthin có thể ngăn ngừa bệnh đường tiêu hóa, bệnh tiểu đường, bệnh tim mạch, và rối loạn thoái hóa thần kinh. Hầu hết các đặc tính này là do khả năng chống oxy hóa cao của astaxanthin, cao hơn nhiều so với các hợp chất tự nhiên đã biết khác. Tuy nhiên, việc phát triển thương mại vẫn còn ở giai đoạn đầu do chi phí sản xuất cao, những khó khăn kỹ thuật trong quá trình chế biến tiếp theo và các vấn đề liên quan đến tính khả dụng sinh học của phân tử sinh học này. Đánh giá hiện tại tập trung vào các ứng dụng công nghiệp của astaxanthin và những thách thức phải đối mặt trong quá trình sản xuất thương mại.
Chi tiết bài viết
Từ khóa
Astaxanthin, carotenoid, chất chống oxy hóa, vi tảo
Tài liệu tham khảo
1. Lafarga T. Effect of microalgal biomass incorporation into foods: Nutritional and sensorial attributes of the end products. Algal Res. 2019;41:101566.
2. Kaha M, Iwamoto K, Yahya NA, Suhaimi N, Sugiura N, Hara H, Othman N, Zakaria Z, Suzuki K. Enhancement of astaxanthin accumulation using black light in Coelastrum and Monoraphidium isolated from Malaysia. Sci Rep. 2021;11 (1):11708.
3. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea F. Astaxanthin: A review of its chemistry and applications. Crit Rev Food Sci Nutr. 2006;46:185-196.
4. Villaro S, Ciardi M, Morillas-Espana A, Sanchez-Zurano A, Acien-Fernandez G, Lafarga T. Microalgae derived astaxanthin: Research and consumer trends and industrial use as food. Foods. 2021;10 (10).
5. Kathiresan S, Chandrashekar A, Ravishankar GA, Sarada R. Regulation of astaxanthin and its intermediates through cloning and genetic transformation of β-carotene ketolase in Haematococcus pluvialis. J Biotechnol. 2015;196-197:33-41.
6. Garrido-Cardenas JA, Manzano-Agugliaro F, Acien-Fernandez FG, Molina-Grima E. Microalgae research worldwide. Algal Res. 2018;35:50-60.
7. Lu Q, Li H, Zou Y, Liu H, Yang L. Astaxanthin as a microalgal metabolite for aquaculture: A review on the synthetic mechanisms, production techniques, and practical application. Algal Res. 2021;54:102178.
8. Vidhyavathi R, Venkatachalam L, Sarada R, Ravishankar GA. Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions. J Exp Bot. 2008;59 (6):1409-1418.
9. Travieso L, Domínguez-Bocanegra A, Rincon B, Sanchez Hernandez E, Benítez F, Borja R, Raposo F, Colmenarejo M. Batch culture growth of Chlorella zofingiensis on effluent derived from two-stage anaerobic digestion of two-phase olive mill solid waste. Electron J Biotechnol. 2008;11: 2-8.
10. Fujii K, Nakashima H, Hashidzume Y, Uchiyama T, Mishiro K, Kadota Y. Potential use of the astaxanthin-producing microalga, Monoraphidium sp. GK12, as a functional aquafeed for prawns. J Appl Phycol. 2010;22 (3):363-369.
11. Barclay MC, Irvin SJ, Williams KC, Smith DM. Comparison of diets for the tropical spiny lobster Panulirus ornatus: astaxanthin-supplemented feeds and mussel flesh. Aquac Nutr. 2006;12 (2):117-125.
12. Lim KC, Yusoff FM, Shariff M, Kamarudin MS. Dietary astaxanthin augments disease resistance of Asian seabass, Lates calcarifer (Bloch, 1790), against Vibrio alginolyticus infection. Fish Shellfish Immunol. 2021;114:90-101.
13. Perenlei G, Tojo H, Okada T, Kubota M, Kadowaki M, Fujimura S. Effect of dietary astaxanthin rich yeast, Phaffia rhodozyma, on meat quality of broiler chickens. Anim Sci J. 2014;85 (10):895-903.
14. Kumar S, Singh SV. Influence of astaxanthin supplementation on attainment of puberty and lipid peroxidation in Sahiwal and Karan Fries (Holstein × Tharparkar) heifers during summer season. Biol Rhythm Res. 2020;51 (1):15-28.
15. Carballo DE, Caro I, Andrés S, Giráldez FJ, Mateo J. Assessment of the antioxidant effect of astaxanthin in fresh, frozen and cooked lamb patties. Food Res Int. 2018;111:342-350.
16. Abdelmalek BE, Sila A, Ghlissi Z, Taktak MA, Ayadi MA, Bougatef A. The influence of natural astaxanthin on the formulation and storage of marinated chicken steaks. J Food Biochem. 2016;40 (4):393-403.
17. Pogorzelska E, Godziszewska J, Brodowska M, Wierzbicka A. Antioxidant potential of Haematococcus pluvialis extract rich in astaxanthin on colour and oxidative stability of raw ground pork meat during refrigerated storage. Meat Sci. 2017;135:54-61.
18. Lafarga T, Gallagher E, Walsh D, Valverde J, Hayes M. Chitosan-containing bread made using marine shellfishery byproducts: Functional, bioactive, and quality assessment of the end product. J Agric Food Chem. 2013;61 (37):8790-8796.
19. Singh KN, Patil S, Barkate H. Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications. J Cosmet Dermatol. 2020;19 (1):22-27.
20. Cheng X-Y, Xiong Y-J, Yang M-M, Zhu M-J. Preparation of astaxanthin mask from Phaffia rhodozyma and its evaluation. Process Biochem. 2019;79:195-202.
21. Astaxanthin Collagen All-in-One Gel: One-Step, Multi-Action Facial Moisturizer. DHC USA Inc. Accessed June 14, 2023 at: https://www.dhccare.com/astaxanthin-collagen-all-in-one-gel.html
22. Lafarga T, Hayes M. Bioactive peptides from meat muscle and by-products: generation, functionality and application as functional ingredients. Meat Sci. 2014;98 (2):227-239.
23. Naguib Y. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem. 2000;48:1150-1154.
24. Turrin NP, Rivest S. Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol. 2006;34 (3):221-242.
25. Galasso C, Orefice I, Pellone P, Cirino P, Miele R, Ianora A, Brunet C, Sansone C. On the neuroprotective role of astaxanthin: New Perspectives? Marine Drugs. 2018;16:247.
26. Bhuvaneswari S, Arunkumar E, Viswanathan P, Anuradha CV. Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed a obesity-promoting diet. Process Biochem. 2010;45 (8):1406-1414.
27. Fakhri S, Aneva I, Farzaei MH, Sobarzo-SÁNchez E. The neuroprotective effects of astaxanthin: Therapeutic targets and clinical perspective. Molecules. 2019;24:2640.
28. Bolin AP, Macedo RC, Marin DP, Barros MP, Otton R. Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. Cell Biol Toxicol. 2010;26 (5):457-467.
29. Lin K-H, Lin K-C, Lu W-J, Thomas P-A, Jayakumar T, Sheu J-R. Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo. Int J Mol Sci. 2016;17 (1):44.
30. Yuan J-P, Peng J, Yin K, Wang J-H. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55 (1):150-165.
31. Torres-Haro A, Verdín J, Kirchmayr MR, Arellano-Plaza M. Metabolic engineering for high yield synthesis of astaxanthin in Xanthophyllomyces dendrorhous. Microb Cell Factories. 2021;20 (1):175.
32. Patel AK, Tambat VS, Chen C-W, Chauhan AS, Kumar P, Vadrale AP, Huang C-Y, Dong C-D, Singhania RR. Recent advancements in astaxanthin production from microalgae: A review. Bioresour Technol. 2022;364:128030.
33. Udayan A, Pandey AK, Sharma P, Sreekumar N, Kumar S. Emerging industrial applications of microalgae: challenges and future perspectives. Syst Microbiol Biomanuf. 2021;1 (4):411-431.
34. Li Q, Li L, Zhang Y, Gao H, Zhao Y, Yu X. Chemical inducers regulate ROS signalling to stimulate astaxanthin production in Haematococcus pluvialis under environmental stresses: A review. Trends Food Sci Technol. 2023;136:181-193.
35. Villaró S, Ciardi M, Morillas-España A, Sánchez-Zurano A, Acién-Fernández G, Lafarga T. Microalgae derived astaxanthin: Research and consumer trends and industrial use as food. Foods. 2021, 10 (10):2303.
36. Greenwell C, Laurens L, Shields R, Lovitt RB, Flynn K. Placing microalgae on the biofuels priority list: A review of the technological challenges. J R Soc Interface. 2010;7:703-726.
37. Bohn T. Bioavailability of non-provitamin a carotenoids. Curr Nutr Food Sci. 2008;4:240-258.
38. Ambati DRR, Lakshmaiah RR, Baskaran V, Sarada R, Gokare R. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. J Agric Food Chem. 2010;58:8553-8559.
2. Kaha M, Iwamoto K, Yahya NA, Suhaimi N, Sugiura N, Hara H, Othman N, Zakaria Z, Suzuki K. Enhancement of astaxanthin accumulation using black light in Coelastrum and Monoraphidium isolated from Malaysia. Sci Rep. 2021;11 (1):11708.
3. Higuera-Ciapara I, Félix-Valenzuela L, Goycoolea F. Astaxanthin: A review of its chemistry and applications. Crit Rev Food Sci Nutr. 2006;46:185-196.
4. Villaro S, Ciardi M, Morillas-Espana A, Sanchez-Zurano A, Acien-Fernandez G, Lafarga T. Microalgae derived astaxanthin: Research and consumer trends and industrial use as food. Foods. 2021;10 (10).
5. Kathiresan S, Chandrashekar A, Ravishankar GA, Sarada R. Regulation of astaxanthin and its intermediates through cloning and genetic transformation of β-carotene ketolase in Haematococcus pluvialis. J Biotechnol. 2015;196-197:33-41.
6. Garrido-Cardenas JA, Manzano-Agugliaro F, Acien-Fernandez FG, Molina-Grima E. Microalgae research worldwide. Algal Res. 2018;35:50-60.
7. Lu Q, Li H, Zou Y, Liu H, Yang L. Astaxanthin as a microalgal metabolite for aquaculture: A review on the synthetic mechanisms, production techniques, and practical application. Algal Res. 2021;54:102178.
8. Vidhyavathi R, Venkatachalam L, Sarada R, Ravishankar GA. Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions. J Exp Bot. 2008;59 (6):1409-1418.
9. Travieso L, Domínguez-Bocanegra A, Rincon B, Sanchez Hernandez E, Benítez F, Borja R, Raposo F, Colmenarejo M. Batch culture growth of Chlorella zofingiensis on effluent derived from two-stage anaerobic digestion of two-phase olive mill solid waste. Electron J Biotechnol. 2008;11: 2-8.
10. Fujii K, Nakashima H, Hashidzume Y, Uchiyama T, Mishiro K, Kadota Y. Potential use of the astaxanthin-producing microalga, Monoraphidium sp. GK12, as a functional aquafeed for prawns. J Appl Phycol. 2010;22 (3):363-369.
11. Barclay MC, Irvin SJ, Williams KC, Smith DM. Comparison of diets for the tropical spiny lobster Panulirus ornatus: astaxanthin-supplemented feeds and mussel flesh. Aquac Nutr. 2006;12 (2):117-125.
12. Lim KC, Yusoff FM, Shariff M, Kamarudin MS. Dietary astaxanthin augments disease resistance of Asian seabass, Lates calcarifer (Bloch, 1790), against Vibrio alginolyticus infection. Fish Shellfish Immunol. 2021;114:90-101.
13. Perenlei G, Tojo H, Okada T, Kubota M, Kadowaki M, Fujimura S. Effect of dietary astaxanthin rich yeast, Phaffia rhodozyma, on meat quality of broiler chickens. Anim Sci J. 2014;85 (10):895-903.
14. Kumar S, Singh SV. Influence of astaxanthin supplementation on attainment of puberty and lipid peroxidation in Sahiwal and Karan Fries (Holstein × Tharparkar) heifers during summer season. Biol Rhythm Res. 2020;51 (1):15-28.
15. Carballo DE, Caro I, Andrés S, Giráldez FJ, Mateo J. Assessment of the antioxidant effect of astaxanthin in fresh, frozen and cooked lamb patties. Food Res Int. 2018;111:342-350.
16. Abdelmalek BE, Sila A, Ghlissi Z, Taktak MA, Ayadi MA, Bougatef A. The influence of natural astaxanthin on the formulation and storage of marinated chicken steaks. J Food Biochem. 2016;40 (4):393-403.
17. Pogorzelska E, Godziszewska J, Brodowska M, Wierzbicka A. Antioxidant potential of Haematococcus pluvialis extract rich in astaxanthin on colour and oxidative stability of raw ground pork meat during refrigerated storage. Meat Sci. 2017;135:54-61.
18. Lafarga T, Gallagher E, Walsh D, Valverde J, Hayes M. Chitosan-containing bread made using marine shellfishery byproducts: Functional, bioactive, and quality assessment of the end product. J Agric Food Chem. 2013;61 (37):8790-8796.
19. Singh KN, Patil S, Barkate H. Protective effects of astaxanthin on skin: Recent scientific evidence, possible mechanisms, and potential indications. J Cosmet Dermatol. 2020;19 (1):22-27.
20. Cheng X-Y, Xiong Y-J, Yang M-M, Zhu M-J. Preparation of astaxanthin mask from Phaffia rhodozyma and its evaluation. Process Biochem. 2019;79:195-202.
21. Astaxanthin Collagen All-in-One Gel: One-Step, Multi-Action Facial Moisturizer. DHC USA Inc. Accessed June 14, 2023 at: https://www.dhccare.com/astaxanthin-collagen-all-in-one-gel.html
22. Lafarga T, Hayes M. Bioactive peptides from meat muscle and by-products: generation, functionality and application as functional ingredients. Meat Sci. 2014;98 (2):227-239.
23. Naguib Y. Antioxidant activities of astaxanthin and related carotenoids. J Agric Food Chem. 2000;48:1150-1154.
24. Turrin NP, Rivest S. Molecular and cellular immune mediators of neuroprotection. Mol Neurobiol. 2006;34 (3):221-242.
25. Galasso C, Orefice I, Pellone P, Cirino P, Miele R, Ianora A, Brunet C, Sansone C. On the neuroprotective role of astaxanthin: New Perspectives? Marine Drugs. 2018;16:247.
26. Bhuvaneswari S, Arunkumar E, Viswanathan P, Anuradha CV. Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed a obesity-promoting diet. Process Biochem. 2010;45 (8):1406-1414.
27. Fakhri S, Aneva I, Farzaei MH, Sobarzo-SÁNchez E. The neuroprotective effects of astaxanthin: Therapeutic targets and clinical perspective. Molecules. 2019;24:2640.
28. Bolin AP, Macedo RC, Marin DP, Barros MP, Otton R. Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. Cell Biol Toxicol. 2010;26 (5):457-467.
29. Lin K-H, Lin K-C, Lu W-J, Thomas P-A, Jayakumar T, Sheu J-R. Astaxanthin, a carotenoid, stimulates immune responses by enhancing IFN-γ and IL-2 secretion in primary cultured lymphocytes in vitro and ex vivo. Int J Mol Sci. 2016;17 (1):44.
30. Yuan J-P, Peng J, Yin K, Wang J-H. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Mol Nutr Food Res. 2011;55 (1):150-165.
31. Torres-Haro A, Verdín J, Kirchmayr MR, Arellano-Plaza M. Metabolic engineering for high yield synthesis of astaxanthin in Xanthophyllomyces dendrorhous. Microb Cell Factories. 2021;20 (1):175.
32. Patel AK, Tambat VS, Chen C-W, Chauhan AS, Kumar P, Vadrale AP, Huang C-Y, Dong C-D, Singhania RR. Recent advancements in astaxanthin production from microalgae: A review. Bioresour Technol. 2022;364:128030.
33. Udayan A, Pandey AK, Sharma P, Sreekumar N, Kumar S. Emerging industrial applications of microalgae: challenges and future perspectives. Syst Microbiol Biomanuf. 2021;1 (4):411-431.
34. Li Q, Li L, Zhang Y, Gao H, Zhao Y, Yu X. Chemical inducers regulate ROS signalling to stimulate astaxanthin production in Haematococcus pluvialis under environmental stresses: A review. Trends Food Sci Technol. 2023;136:181-193.
35. Villaró S, Ciardi M, Morillas-España A, Sánchez-Zurano A, Acién-Fernández G, Lafarga T. Microalgae derived astaxanthin: Research and consumer trends and industrial use as food. Foods. 2021, 10 (10):2303.
36. Greenwell C, Laurens L, Shields R, Lovitt RB, Flynn K. Placing microalgae on the biofuels priority list: A review of the technological challenges. J R Soc Interface. 2010;7:703-726.
37. Bohn T. Bioavailability of non-provitamin a carotenoids. Curr Nutr Food Sci. 2008;4:240-258.
38. Ambati DRR, Lakshmaiah RR, Baskaran V, Sarada R, Gokare R. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. J Agric Food Chem. 2010;58:8553-8559.